Lipid Modifications of Sonic Hedgehog Ligand Dictate Cellular Reception and Signal Response
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چکیده
منابع مشابه
Lipid Modifications of Sonic Hedgehog Ligand Dictate Cellular Reception and Signal Response
BACKGROUND Sonic hedgehog (Shh) signaling regulates cell growth during embryonic development, tissue homeostasis and tumorigenesis. Concentration-dependent cellular responses to secreted Shh protein are essential for tissue patterning. Shh ligand is covalently modified by two lipid moieties, cholesterol and palmitate, and their hydrophobic properties are known to govern the cellular release and...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0021353